C-peptide in Serum
C-peptide ranges
What a low value may mean:
Common reasons for low C-peptide:
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Low C-peptide reflects reduced endogenous insulin production — classically type 1 diabetes and LADA (autoimmune beta-cell destruction), and late-stage type 2 diabetes with beta-cell exhaustion.
Other causes: exogenous insulin therapy suppressing pancreatic secretion, pancreatectomy or pancreatic damage, and prolonged fasting or low food intake.
What a high value may mean:
Common reasons for high C-peptide:
- ,,
High C-peptide reflects excess endogenous insulin production — most often the compensatory hyperinsulinemia of insulin resistance seen in obesity, metabolic syndrome, and early type 2 diabetes.
Other causes: insulinoma (insulin-secreting tumor), Cushing's syndrome, insulin-stimulating drugs such as sulfonylureas, and reduced renal clearance in kidney insufficiency.
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